CD31 (N-term) polyclonal HRP, anti-human, mouse, rat, bovine, pig, sheep

Protein Family: Cell Adhesion Molecules, Enzymes, CAM Ligands, Cellular antigens, Glycan binding proteins

Pathway and Disease: Signaling Molecules and Interaction, Immune System

Description:
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily.

Alternate Names: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, CPIIA', CD31 antigen, PECAM1

Application Notes: HRP-conjugated format of Cat. No. 250589. E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P16284

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD31.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA and 0.02% gentamicin. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Product is guaranteed 6 months from the date of shipment.