CD31 polyclonal, anti-human, mouse, bovine, pig, sheep
€378.00
In stock
SKU
250590
Catalog Nr.: 250590
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IP, IF
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IP, IF
Protein Family: Cell Adhesion Molecules, Enzymes, CAM Ligands, Cellular antigens, Glycan binding proteins
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily. CD31 is often used as a marker of the vascular endothelium.
Alternate Names: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, CPIIA', CD31 antigen, PECAM1
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P16284
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PECAM1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Hogan M et al. 2016. Aims Bioengineering. 3(3): 277-88.
[2] Florida SE et al. 2016. Connect Tissue Res. PMID 27184487.
[3] Huang H et al. 2016. J Neuroinflammation. PMID 27586239.
[4] Hall A. et al. 2016. Toxicol Pathol. PMID 26534939.
[5] Malik I. et al. 2015. J Cell Mol Med. PMID 26177067.
[6] Foubert P et al. 2015. Burns. PMID 26059048.
[7] Chen T et al. 2015. Stem Cells. PMID 25535084.
[8] Di Bernardini et al. 2014. J Biol Chem. PMID 24356956.
[9] Guo R et al. 2014. Wound Repair Regen. PMID 24844338.
[10] Hsu DSS et al. 2014. Cancer Cell. PMID 25314079.
[11] Beokema B et al. 2014. J Mat Science Mat Med. PMID 24178984.
[12] Chang K et al. 2013. Acta Biomaterialia. PMID 23851171.
[13] Tepekoylu C et al. 2013. J Thoracic Card Surgery. PMID 23395097.
[14] Boldt J et al. 2012. Tissue Eng Part C Met. PMID 23098227.
[15] Yu G et al. 2012.Tumor Biology. PMID 22076923.
[16] Williams M et al. 2012. J Tissue Eng Regen Med. PMID 22328229.
[17] Kinoshita N et al. 2012. Wound Repair Regen. PMID 22276588.
[18] Ma J et al. 2012. Tissue Engineering Part A. PMID 21902608.
[19] Feng X. et al. 2009. J. Am. Soc. Nephrol. PMID 19608706.
Pathway and Disease: Signaling Molecules and Interaction, Immune System
Description:
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily. CD31 is often used as a marker of the vascular endothelium.
Alternate Names: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, CPIIA', CD31 antigen, PECAM1
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P16284
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PECAM1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Hogan M et al. 2016. Aims Bioengineering. 3(3): 277-88.
[2] Florida SE et al. 2016. Connect Tissue Res. PMID 27184487.
[3] Huang H et al. 2016. J Neuroinflammation. PMID 27586239.
[4] Hall A. et al. 2016. Toxicol Pathol. PMID 26534939.
[5] Malik I. et al. 2015. J Cell Mol Med. PMID 26177067.
[6] Foubert P et al. 2015. Burns. PMID 26059048.
[7] Chen T et al. 2015. Stem Cells. PMID 25535084.
[8] Di Bernardini et al. 2014. J Biol Chem. PMID 24356956.
[9] Guo R et al. 2014. Wound Repair Regen. PMID 24844338.
[10] Hsu DSS et al. 2014. Cancer Cell. PMID 25314079.
[11] Beokema B et al. 2014. J Mat Science Mat Med. PMID 24178984.
[12] Chang K et al. 2013. Acta Biomaterialia. PMID 23851171.
[13] Tepekoylu C et al. 2013. J Thoracic Card Surgery. PMID 23395097.
[14] Boldt J et al. 2012. Tissue Eng Part C Met. PMID 23098227.
[15] Yu G et al. 2012.Tumor Biology. PMID 22076923.
[16] Williams M et al. 2012. J Tissue Eng Regen Med. PMID 22328229.
[17] Kinoshita N et al. 2012. Wound Repair Regen. PMID 22276588.
[18] Ma J et al. 2012. Tissue Engineering Part A. PMID 21902608.
[19] Feng X. et al. 2009. J. Am. Soc. Nephrol. PMID 19608706.
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