CD319 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7859
Background:
CS1, also known as novel Ly9, SLAMF7, CD319, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCγ and PI 3-kinase. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
Alternative Name:
19A, CD319, CRACC, CS1, SLAMF7
Application Dilution: WB: 1:500~1:2000
Specificity: CD319 polyclonal antibody detects endogenous levels of CD319 protein.
Immunogen:
Recombinant full length Human CD319.
MW: ~ 37 kDa
Swis Prot.: Q9NQ25
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
CS1, also known as novel Ly9, SLAMF7, CD319, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCγ and PI 3-kinase. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
Alternative Name:
19A, CD319, CRACC, CS1, SLAMF7
Application Dilution: WB: 1:500~1:2000
Specificity: CD319 polyclonal antibody detects endogenous levels of CD319 protein.
Immunogen:
Recombinant full length Human CD319.
MW: ~ 37 kDa
Swis Prot.: Q9NQ25
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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