CD32-B polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61761
Background:
CD32 (also designated Fc γ RII) is a low affinity receptor for the Fc fragment of aggregated IgG. CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells. IgG can noncooperatively bind either one or two highly glycosylated CD32 molecules, and this binding delivers a negative signal for B cells. CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B, and C. These isoforms are designated Fc γ RIIA, Fc γ RIIB1, Fc γ RIIB3, and Fc γ RIIC. All isoforms are present on monocytes, placental trophoblasts and endothelial cells. In addition, the Fc γ RIIB forms are present on B lymphocytes, and the Fc γ RIIA and Fc γ RIIC forms are found on neutrophils.
Alternative Name:
Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2
Application Dilution: WB: 1:500~1:1000
Specificity: CD32-B polyclonal antibody detects endogenous levels of CD32-B protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 250-300 of Human FCGR2B.
MW: ~ 34 kDa
Swis Prot.: P31994
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
CD32 (also designated Fc γ RII) is a low affinity receptor for the Fc fragment of aggregated IgG. CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells. IgG can noncooperatively bind either one or two highly glycosylated CD32 molecules, and this binding delivers a negative signal for B cells. CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B, and C. These isoforms are designated Fc γ RIIA, Fc γ RIIB1, Fc γ RIIB3, and Fc γ RIIC. All isoforms are present on monocytes, placental trophoblasts and endothelial cells. In addition, the Fc γ RIIB forms are present on B lymphocytes, and the Fc γ RIIA and Fc γ RIIC forms are found on neutrophils.
Alternative Name:
Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2
Application Dilution: WB: 1:500~1:1000
Specificity: CD32-B polyclonal antibody detects endogenous levels of CD32-B protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 250-300 of Human FCGR2B.
MW: ~ 34 kDa
Swis Prot.: P31994
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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