CD331 (FGFR1) (clone 3D4F7), anti-human
€394.00
In stock
SKU
252899
Catalog Nr.: 252899
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: WB
Protein Family: Enzymes, Protein Kinases, Receptors and Channels
Pathway and Disease: Cancers, Development and Behavior, Replication and Repair, Signal Transduction, Transcription
Description:
FGFR1 (Basic fibroblast growth factor receptor 1) is a membrane receptor for basic fibroblast growth factor (FGF2) and for acidic fibroblast growth factor (FGF1). Binding of FGF and heparin leads to receptor dimerization and autophosphorylation at 7 tyrosine residues in the cytoplasmic tail. Phosphorylation of tyrosine 653 and 654 are important for catalytic activity while other sites may provide docking sites for downstream signaling components such as Crk and PLCgamma. FGFR1 also interacts with SHB, KLB, FGF23, GRB10. FGFR1 activation influences mitogenesis and differentiation of various cell types. Mutations and chromosomal aberrations are associated with various disorders including Pfeiffer Syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, stem cell leukemia lymphoma syndrome and stem cell myeloproliferative disorder.
Alternate Names: FGFR1, Fibroblast growth factor receptor 1, Basic fibroblast growth factor receptor 1, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, c-fgr, CD331, FLT-2, FGFBR, FLG, FLT2
Application Notes: WB: 1:500-1:2000
Accession No.: P11362
Antigen: Purified recombinant extracellular fragment of human FGFR1(aa33-423) fused with hIgGFc tag expressed in HEK293 cells.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Development and Behavior, Replication and Repair, Signal Transduction, Transcription
Description:
FGFR1 (Basic fibroblast growth factor receptor 1) is a membrane receptor for basic fibroblast growth factor (FGF2) and for acidic fibroblast growth factor (FGF1). Binding of FGF and heparin leads to receptor dimerization and autophosphorylation at 7 tyrosine residues in the cytoplasmic tail. Phosphorylation of tyrosine 653 and 654 are important for catalytic activity while other sites may provide docking sites for downstream signaling components such as Crk and PLCgamma. FGFR1 also interacts with SHB, KLB, FGF23, GRB10. FGFR1 activation influences mitogenesis and differentiation of various cell types. Mutations and chromosomal aberrations are associated with various disorders including Pfeiffer Syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, stem cell leukemia lymphoma syndrome and stem cell myeloproliferative disorder.
Alternate Names: FGFR1, Fibroblast growth factor receptor 1, Basic fibroblast growth factor receptor 1, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, c-fgr, CD331, FLT-2, FGFBR, FLG, FLT2
Application Notes: WB: 1:500-1:2000
Accession No.: P11362
Antigen: Purified recombinant extracellular fragment of human FGFR1(aa33-423) fused with hIgGFc tag expressed in HEK293 cells.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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