CD35 (clone E11) FITC, anti-human RUO

This antibody reacts with the CD35-antigen, a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, follicular dendritic cells, as well as the subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.

Recomended usage
CD35, clone E11 is a mAb intended for identify/enumerate granulocytes, monocytes, B cells, erythrocytes, FDCs, subsets of NK and T cells by FCM. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/10^6 cells.