CD36 (clone EBS-CD-023), anti-human

Source:
A BALB/c mouse was immunized with gp88 purified from human platelets.
Fusion partner: SP2/0.



Specifications:
CD36 is a 80-90 kDa protein, expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P.falciparum malaria-infected erythrocytes, and sickle erythrocytes. CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria.

Species reactivity:
Positive: human.

Applications:
Demonstration of CD36. Staining of TSH activated endothelial cells, granular layer of skin, monocytes/macrophages, erythroblasts, B-cell (weak), adipocytes.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: +

Positive control: HEL, U937 or C32 melanoma cells. Platelets, monocytes, macrophages, umbilical vein endothelium, microvascular endothelial cells in tonsil.

References:
- Biggs et al, J. Exp. Med.171: 1883-1892 (1990).
- Stomski et al. Exp. Cell Res.198: 85 92 (1992)