CD38 (clone FS02), anti-human

Source:
A BALB/c mouse was immunized with the human T-cell line CCRF-CEM.
Fusion partner: X63-Ag8.653.



Specifications:
FS02 reacts with a 45 kDa glycopeptide which is a type II membrane glycoprotein with a transmembrane sequence near the NH2 terminus, involved in the regulation of lymphocyte adhesion to endothelial cells. Its ligand is CD31. CD38 is found on early cells of B and T lineages and on activated T and B-cells. It is not found on most mature resting peripheral lymphocytes. Also positive are thymus cells and Ig secreting plasma cells. The CD34+ + CD38- population of hematopoietic stems cells defines the most pluripotent cells (e.g. blast colony forming cells).

Species reactivity:
Positive: human.

Applications:
Subtyping of lymphomas and leukemias(many ALL’s, some AML’s). Detection of plasma cells (myelomas). Marker for B- and T-cell activation by flow cytometry and immunohistology.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: -

Positive control: CCRF-CEM cells, tonsil, spleen or skin.

References:
- Deaglio,S.,et. al. J Immunol.160(1):395-402(1998).