CD40 (clone HI40a), anti-human

Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens, Receptors and Channels

Pathway and Disease: Immune System, Signaling Molecules and Interaction

Description:
The CD40 (HI40a) antibody recognizes a 48-kDa type-I single chain transmembrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells. CD40 antigen is also present on Hodgkin and Reed-Sternberg cells, follicular dendritic cells, some macrophages, basal epithelial cells and endothelial cells. The ligand for CD40 is CD154 (CD40L). CD40 is involved in growth, differentiation, isotype-switching on B cells and rescuing B cells from apoptosis.

Alternate Names: CD40, Tumor necrosis factor receptor superfamily member 5, CD40L receptor, B-cell surface antigen CD40, Bp50, CDw40, TNFRSF5

Application Notes: E: 1:500-1:1,000; FC: 1:200-1:1,000

Accession No.: P25942

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.