CD40L polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
251649
Catalog Nr.: 251649
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens, Cytokines
Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Immune System, Infectious Diseases
Description:
CD40L mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4, and is involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1, also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Alternate Names: CD40-L, CD40 ligand, TNFSF5, CD154, Tumor necrosis factor ligand superfamily member 5, TRAP, T-cell antigen Gp39, CD40LG, CD40L
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P29965
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD40L.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Immune System, Infectious Diseases
Description:
CD40L mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4, and is involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1, also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Alternate Names: CD40-L, CD40 ligand, TNFSF5, CD154, Tumor necrosis factor ligand superfamily member 5, TRAP, T-cell antigen Gp39, CD40LG, CD40L
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P29965
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD40L.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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