CD42b (clone HIP1) FITC, anti-human
€390.00
In stock
SKU
251022
Catalog Nr.: 251022
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Protein Family: Cell Adhesion Molecules, Cellular Antigens, Receptors and Channels
Pathway and Disease: Immune System, Signaling Molecules and Interaction
Description:
The CD42b (HIP1) antibody recognizes a heterodimer glycoprotein (GPIbα) that contains an α chain (CD42b, 145 kDa) and a β chain (CD42c, 22 kDa) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. CD42b antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). The CD42b (HIP1) antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation.
Alternate Names: CD42b, Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha, GPIbA, Antigen CD42b-alpha, Glycocalicin
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P07359
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Chen Z., et al. 1987. Chinese Science Bulletin. 24: 1902
Knapp W., et al., eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P798, 1078, Oxford University Press, New York.
Pathway and Disease: Immune System, Signaling Molecules and Interaction
Description:
The CD42b (HIP1) antibody recognizes a heterodimer glycoprotein (GPIbα) that contains an α chain (CD42b, 145 kDa) and a β chain (CD42c, 22 kDa) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. CD42b antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). The CD42b (HIP1) antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation.
Alternate Names: CD42b, Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha, GPIbA, Antigen CD42b-alpha, Glycocalicin
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P07359
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Chen Z., et al. 1987. Chinese Science Bulletin. 24: 1902
Knapp W., et al., eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P798, 1078, Oxford University Press, New York.
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