CD44 polyclonal, anti-human, mouse, rat

Protein Family: Proteoglycans, CAM Ligands, Cell Adhesion Molecules, Cellular Antigens

Pathway and Disease: Signaling Molecules and Interaction, Immune System, Infectious Diseases

Description:
CD44 antigen (CD44) is a receptor for hyaluronic acid (HA). CD44 mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). The adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.

Alternate Names: CD44, CD44 antigen, Phagocytic glycoprotein I, PGP-I, HUTCH-I, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, Hyaluronate receptor, Heparan sulfate proteoglycan, Epican, CDw44

Application Notes: E: 1:1,000-1:5,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P16070

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD44.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Su Y et al. 2016. Cancer Med. 5(3): 558-73. PMID 26775583.
[2] Thompson SM et al. 2014. Cardiovasc Intervent Radiol. doi: 10.1007/s0027-013-0828-3. PMID 24452318.