CD45 polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
251175
Catalog Nr.: 251175
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: CAM Ligands, Cellular Antigens, Enzymes
Pathway and Disease: Immune System, Neurodegenerative Disorders, Signaling Molecules and Interaction
Description:
The CD45 antigen (Receptor-type tyrosine-protein phosphatase C, PTPRC) is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. CD45 acts as a positive regulator of T-cell coactivation upon binding to DPP4. Defects in CD45 are a cause of severe combined immunodefiency autosomal recessive T-cell negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID). Genetic variations in CD45 are involved in multiple sclerosis susceptibility.
Alternate Names: Leukocyte common antigen, L-CA, T200, CD45 antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, CD45
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P08575
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD45.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Karaca T et al. 2015. Iran J Basic Med Sci. 18(4): 370-379. PMID 26019800.
[2] Karaca T et al. 2011. Allergologia Immunopathologia. 40(6): 357-361. PMID 22115572.
Pathway and Disease: Immune System, Neurodegenerative Disorders, Signaling Molecules and Interaction
Description:
The CD45 antigen (Receptor-type tyrosine-protein phosphatase C, PTPRC) is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. CD45 acts as a positive regulator of T-cell coactivation upon binding to DPP4. Defects in CD45 are a cause of severe combined immunodefiency autosomal recessive T-cell negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID). Genetic variations in CD45 are involved in multiple sclerosis susceptibility.
Alternate Names: Leukocyte common antigen, L-CA, T200, CD45 antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, CD45
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P08575
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD45.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Karaca T et al. 2015. Iran J Basic Med Sci. 18(4): 370-379. PMID 26019800.
[2] Karaca T et al. 2011. Allergologia Immunopathologia. 40(6): 357-361. PMID 22115572.
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