CD48 (clone EBS-CD-030), anti-human

Source:
A BALB/c mouse was immunized with human PBL.
Fusion partner: NS-1.



Specifications:
CD48 is 45 kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein, highly expressed on lymphocytes and monocytes and weakly on granulocytes. Platelets, fibroblasts, epithelium and endothelium are negative. CD48 is one of the markers for detecting the GPI anchoring defect in patients with paroxysmal nocturnal hemoglobinuria (PNH). Also serves as a low affinity ligand for CD2.

Species reactivity:
Positive: human.

Applications:
CD48 can indicate the condition of paroxysmal nocturnal hemoglobinuria (PNH).
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +

Positive control: Daudi, JY, Raji, Jurkat, and human lymphocytes. Human lymph node and tonsil.

References:
- Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, New York and London, (1997).
- Yokoyama S et al. J Immunol146(7): 2192-2200 (1991).
- Kwong YL et al. Am J Clin Pathol102(1): 30-35 (1994).
- Sandrin MS et al..J Immunol, 151(9): 4606-4613 (1993).
- Vaughan HA et al, Transplantation36: 446-450 (1983).
- Vaughan HA et al, Immunogenetics33: 113-117 (1991)