CD5 (clone CRIS-1), anti-human, rhesus monkey

Source:
A BALB/c mouse was immunized with stimulating human leukocytes.
Fusion partner: NS-1.



Specifications:
Cris-1 reacts with a 67 kDa protein, consistent with human CD5. Cris-1 was assigned at the Ist and IIIrd International Leucocyte Typing Workshops. CD5 is a pan T-cell marker that also reacts with a B-cell marker subset and a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in the diagnosis of mature T-cell neoplasms.

Species reactivity:
Positive: human, rhesus monkey.

Applications:
CD5 is a marker for mantle cell lymphoma. Aberrant expression is useful in making a diagnosis of mature T-cell neoplasms.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Immunoprecipitation: +

Positive control: 293T, Ramos, or MOLT-4 Cells. Tonsil.

References:
- Proceedings of the first international workshop and conference on human leukocyte differentiation antigens. Oxford University Press, Oxford(1983).
- Leukocyte Typing III, McMichael A. J. et al. (Eds.), Oxford University Press, Oxford (1987).
- Alberola-Ila J, et al, J Immunol.148(5):1287-93 (1992).
- Arrizabalaga P. et al, Nephron53: 41-49 (1989).
- Guarne A. et al, Protein Science5: 167-169 (1996).