CD52 (clone HI186), anti-human
€323.00
In stock
SKU
250971
Catalog Nr.: 250971
Size: 0.1 mg
Isotype: mouse IgG2b
Applications: E, FC, IHC
Size: 0.1 mg
Isotype: mouse IgG2b
Applications: E, FC, IHC
Protein Family: Cellular Antigens
Pathway and Disease: Immune System, Signaling Molecules and Interaction
Description:
The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically expressed at high levels on thymocytes, lymphocytes, NK cells, monocytes/macrophages. CD52 is expressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also expressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype.
Alternate Names: CD52, CAMPATH-1 antigen, Cambridge pathology 1 antigen, Epididymal secretory protein E5, CDw52
Application Notes: Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen and formalin-fixed paraffin sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500
Accession No.: P31358
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Tadamitsu K et al. eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P49-52, 113-114 Garland Publishing Inc. New York.
Pathway and Disease: Immune System, Signaling Molecules and Interaction
Description:
The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically expressed at high levels on thymocytes, lymphocytes, NK cells, monocytes/macrophages. CD52 is expressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also expressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype.
Alternate Names: CD52, CAMPATH-1 antigen, Cambridge pathology 1 antigen, Epididymal secretory protein E5, CDw52
Application Notes: Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen and formalin-fixed paraffin sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500
Accession No.: P31358
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Tadamitsu K et al. eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P49-52, 113-114 Garland Publishing Inc. New York.
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