CD56 (N-CAM) (clone EBS-CD-033), anti-human

Source:
A BALB/c mouse was immunized with a crude membrane preparation of a small cell lung cancer.
Fusion partner: SP2/0.



Specifications:
EBS-CD-033 reacts with an extracellular domain (close to the cell membrane) of CD56/NCAM. Only 2 isoforms of NCAM are recognized by EBS-CD-033 (180 kDa and 145 kDa). EBS-CD-033 was used successfully for immunoscintigraphy and immunotherapy of SCLC xenografts in nude mice. EBS-CD-033 recognizes NCAM in retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell lung carcinomas. NCAM is also expressed on some mesodermally derived tumors (a.o. rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

Species reactivity:
Positive: human.

Applications:
Differential diagnosis involving neuroectodermally derived tumors e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, small cell carcinomas, but also NK/T-cell lymphomas.
ELISA: +
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: Citrate
Western blotting: +

Positive control: Cerebellum, pancreas, neuroblastoma.

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