CD57 (clone HI57a) PE, anti-human
€390.00
In stock
SKU
251086
Catalog Nr.: 251086
Size: 2 ml
Isotype: mouse IgM
Applications: FC
Size: 2 ml
Isotype: mouse IgM
Applications: FC
Protein Family: Cellular Antigens, Enzymes, Glycosyltransferases
Pathway and Disease: Glycan Biosynthesis and Metabolism, Immune System, Signaling Molecules and Interaction
Description:
The CD57 (HI57a) antibody recognizes a 110-115 kDa carbohydrate antigen also called B3GAT1, HNK-1 and Leu7. CD57 antigen is expressed on 12-20% of normal peripheral blood lymphocytes including subsets of NK cells and CD8+ Ts/Tc. CD57 expression increases with age in peripheral blood lymphocytes to 25-40% in patients over 80 year-old. CD57 is not expressed by cord blood lymphocytes, B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. CD57+ cell population increases in pathologies characterized by an imbalance of CD4/CD8 lymphocytes, e.g. AIDS, autoimmune diseases, allograft transplants, and viral infections. The CD57 molecule is shared by normal neural and striated muscle and their neoplastic counterparts including neurofibromas, neurofibrosarcomas and malignant melanomas. CD57 is also present on normal and neoplastic prostatic epithelia, where it represents a prognostic factor showing a positive correlation between the number of CD57+ cells and an increased survival of the neoplastic patients.
Alternate Names: Beta-1, 3-glucuronyltransferase 1, Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, Glucuronosyltransferase-P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1, 3-glucuronyltransferase, GlcUAT-P, B3GAT1, GLCATP, HNK-1, HSO(3)-3GlcAbeta1-3Galbeta1-4GlcNAc-, Leu7, CD57
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: Q9P2W7
Format: Each vial contains 2 ml IgM (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by hydroxyapatite chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Tadamitsu K. et al., eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P49-52, 113-114 Garland Publishing, Inc., New York.
Pathway and Disease: Glycan Biosynthesis and Metabolism, Immune System, Signaling Molecules and Interaction
Description:
The CD57 (HI57a) antibody recognizes a 110-115 kDa carbohydrate antigen also called B3GAT1, HNK-1 and Leu7. CD57 antigen is expressed on 12-20% of normal peripheral blood lymphocytes including subsets of NK cells and CD8+ Ts/Tc. CD57 expression increases with age in peripheral blood lymphocytes to 25-40% in patients over 80 year-old. CD57 is not expressed by cord blood lymphocytes, B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. CD57+ cell population increases in pathologies characterized by an imbalance of CD4/CD8 lymphocytes, e.g. AIDS, autoimmune diseases, allograft transplants, and viral infections. The CD57 molecule is shared by normal neural and striated muscle and their neoplastic counterparts including neurofibromas, neurofibrosarcomas and malignant melanomas. CD57 is also present on normal and neoplastic prostatic epithelia, where it represents a prognostic factor showing a positive correlation between the number of CD57+ cells and an increased survival of the neoplastic patients.
Alternate Names: Beta-1, 3-glucuronyltransferase 1, Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, Glucuronosyltransferase-P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1, 3-glucuronyltransferase, GlcUAT-P, B3GAT1, GLCATP, HNK-1, HSO(3)-3GlcAbeta1-3Galbeta1-4GlcNAc-, Leu7, CD57
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: Q9P2W7
Format: Each vial contains 2 ml IgM (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by hydroxyapatite chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Tadamitsu K. et al., eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P49-52, 113-114 Garland Publishing, Inc., New York.
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