CD57 (clone NK-1), anti-human

Source:
A BALB/c mouse was immunized with human PBL.
Fusion partner: NS-1.



Specifications:
NK-1 reacts with CD57, a 110 kDa antigen present on the surface of human NK-cells and T-cell subsets. In adult peripheral blood 20% of mononuclear cells are positive. Other positive tissues include peripheral nerves (myelin-associated glycoprotein) and prostate. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastomas. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5, and CEA.

Species reactivity:
Positive: human.

Applications:
Identify NK-cells and neuroendocrine differentiation and or derivation.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sectionsTris/EDTA

Positive control: Lymph node or tonsil.

References:
- Abo T et al J. Immunol127:1024 (1981).
- Abo T et al. J Immunol129(4):1752-7 (1982).
- Abo T et al. J Immunol129(4):1758-61 (1982).
- McGarry, RC et al. Nature306:376 (1983).
- Lanier, LL et al. J. Immunology131:1789 (1983)