CD6 (clone HI210) FITC, anti-human
€390.00
In stock
SKU
250995
Catalog Nr.: 250995
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Protein Family: CAM Ligands, Cellular Antigens
Pathway and Disease: Immune System
Description:
The CD6 (HI210) Antibody recognizes a 100-130 kDa type-I single-chain transmembrane glycoprotein, a receptor for CD166. CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. CD6 is also expressed at high levels on peripheral blood T cells and at low levels on most peripheral blood B cells. High levels of CD6 are present in T-cell malignancies and certain B-cell malignancies including B-CLL. CD6 not only is expressed on all CD5+ B-CLL, but also on CD5- B-CLL, suggesting a broader distribution of CD6 than CD5 in B-cell malignancies. CD6 has also been found recently to be expressed in a minor subset of myeloid malignancies. CD6 functions as an adhesion molecule as well as a costimulatory molecule for T cell activation.
Alternate Names: T-cell differentiation antigen CD6, T12, TP120, CD6 antigen, CD6
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P30203
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York.
Pathway and Disease: Immune System
Description:
The CD6 (HI210) Antibody recognizes a 100-130 kDa type-I single-chain transmembrane glycoprotein, a receptor for CD166. CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. CD6 is also expressed at high levels on peripheral blood T cells and at low levels on most peripheral blood B cells. High levels of CD6 are present in T-cell malignancies and certain B-cell malignancies including B-CLL. CD6 not only is expressed on all CD5+ B-CLL, but also on CD5- B-CLL, suggesting a broader distribution of CD6 than CD5 in B-cell malignancies. CD6 has also been found recently to be expressed in a minor subset of myeloid malignancies. CD6 functions as an adhesion molecule as well as a costimulatory molecule for T cell activation.
Alternate Names: T-cell differentiation antigen CD6, T12, TP120, CD6 antigen, CD6
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P30203
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York.
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