CD62P (clone HI62P), anti-human

Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens, Glycan Binding Proteins

Pathway and Disease: Immune System, Signaling Molecules and Interaction

Description:
The CD62P (HI62P) antibody recognizes a 140-kDa long single chain type-I transmembrane glycoprotein, P-selectin, also called granule membrane protein-140 (GMP-140) or platelet activation dependent granule-external membrane protein (PADGEM). CD62P antigen is present in the α-granules of platelets and in Weibel-Palade bodies of endothelial cells, and is rapidly mobilized from storage granules to the cell surface after cell activation. CD62P is expressed on the surface of the activated platelets. Interaction of CD62P with PSGL-1 (CD162) mediates tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration towards sites of inflammation. CD62P also mediates rolling of platelets on endothelial cells and CD62P-mediated interactions involved in platelet-mediated delivery of lymphocytes to high endothelial venules (HEV). Defects in CD62P is a cause of susceptibility to ischemic stroke.

Alternate Names: CD62P, P-selectin, Granule membrane protein 140, GMP-140, PADGEM, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, CD62 antigen-like family member P, SELP

Application Notes: E: 1:500-1:1,000; FC: 1:200-1:1,000

Accession No.: P16109

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.