CD66e (CEA) (clone CB30), anti-human

Source:
A BALB/c mouse was immunized with human colon cancer extract.
Fusion partner: SP2/0.



Specifications:
CB-30 reacts with CD66e or CEA with MW of 80-200 kDa. CEA is present in fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. CEAis not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Ant-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbladder, urachus, salivary gland, ovary, and endocervix.

Species reactivity:
Positive: human.

Applications:
Demonstration of CEA in oncology.
ELISA: +
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: Citrate

Positive control: MCF7 cells, 293T cells, colon carcinoma.

References:
- AshleyNet. al. J Pathol. 234(1):34-45(2014)