CD68 polyclonal, anti-mouse, rat
€378.00
In stock
SKU
250594
Catalog Nr.: 250594
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Protein Family: Cell Adhesion Molecules, Cellular Antigens, Receptors and Channels
Pathway and Disease: Cancers, Cell Motility, Immune System
Description:
The CD68 antigen is involved in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 binds to tissue- and organ-specific lectins and selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane helps macrophages to move over selectin-bearing substrates and other cells. CD68 is highly expressed by blood monocytes and tissue macrophages as well as many tumor cell lines promoting binding to selectins on vascular endothelium facilitating dissemination to secondary sites.
Alternate Names: Macrosialin, Gp110, CD68
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500; IF: 1:100-1:500
Accession No.: P31996
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse CD68.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zalfa C et al. 2016. Cell Death Dis. 7(8): e2311. PMID 27512952.
[2] Alcalá M. et al. 2015. Obesity (Silver Spring). 23(8):1598-606. PMID 26148343.
[3] Hsieh C-H. et al. 2013. PLOS One. 8(9) e72917.
[4] Muller I et al. 2013. J Biol Chem. 288(44): 31635-45. PMID 24003215.
[5] Borrione P et al. 2013. Blood Transfus. Doi: 10.2450/2013.0275-12
[6] Li D et al. 2013. Oncogene. doi:10.1038/onc.2013.75. PMID 23563178.
[7] Day R et al. 2013. Amer J Physiology-Renal Physiology. doi: 10.1152/ajprenal.00306. PMID 23303408.
[8] Kim E et al. 2011. Breast Cancer Research. 13(4):R78. PMID 21834963.
[9] Park H et al. 2011. Molecular Carcinogenesis. 51(11):869-880. PMID 21919080.
[10] Wu JB et al. 2010. Bioscience, Biotechnology, and Biochemistry. 74(4):781-787.PMID 20378990.
Pathway and Disease: Cancers, Cell Motility, Immune System
Description:
The CD68 antigen is involved in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 binds to tissue- and organ-specific lectins and selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane helps macrophages to move over selectin-bearing substrates and other cells. CD68 is highly expressed by blood monocytes and tissue macrophages as well as many tumor cell lines promoting binding to selectins on vascular endothelium facilitating dissemination to secondary sites.
Alternate Names: Macrosialin, Gp110, CD68
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500; IF: 1:100-1:500
Accession No.: P31996
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse CD68.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zalfa C et al. 2016. Cell Death Dis. 7(8): e2311. PMID 27512952.
[2] Alcalá M. et al. 2015. Obesity (Silver Spring). 23(8):1598-606. PMID 26148343.
[3] Hsieh C-H. et al. 2013. PLOS One. 8(9) e72917.
[4] Muller I et al. 2013. J Biol Chem. 288(44): 31635-45. PMID 24003215.
[5] Borrione P et al. 2013. Blood Transfus. Doi: 10.2450/2013.0275-12
[6] Li D et al. 2013. Oncogene. doi:10.1038/onc.2013.75. PMID 23563178.
[7] Day R et al. 2013. Amer J Physiology-Renal Physiology. doi: 10.1152/ajprenal.00306. PMID 23303408.
[8] Kim E et al. 2011. Breast Cancer Research. 13(4):R78. PMID 21834963.
[9] Park H et al. 2011. Molecular Carcinogenesis. 51(11):869-880. PMID 21919080.
[10] Wu JB et al. 2010. Bioscience, Biotechnology, and Biochemistry. 74(4):781-787.PMID 20378990.
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