CD7 (clone BF12), anti-human

Source:
A BALB/c mouse was immunized with CLL cells.
Fusion partner: NS-1



Specifications:
BF12 recognizes 40 kDa CD7, a member of the immunoglobulin gene superfamily and expressed on the majority of immature and mature T-lymphocytes, and T-cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B-cells and on malignant B-cells. CD7 associates directly with phosphoinositol 3’-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Species reactivity:
Positive: human.

Applications:
Characterization of Leukemia and lymphoma.
Flow cytometry : +
Frozen sections: +
Immunofluorescence: +
Paraffin section: ―

Positive control: Jurkat, HUT-78, Molt-4, CEM cells, or human PBL. Lymph node and tonsil.

References:
- Wang, MY et. al, Bone Marrow Transplant.9(5):319-23(1992).