CD71 (clone HI166) FITC, anti-human
€390.00
In stock
SKU
251035
Catalog Nr.: 251035
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Protein Family: Cellular Antigens, Transporters
Pathway and Disease: Immune System, Membrane Transport, Signaling Molecules and Interaction
Description:
The CD71 (HI166) Antibody recognizes a 95-kDa disulfide-bonded homodimeric type-II transmembrane glycoprotein called transferring receptor (TfR). CD71 antigen is expressed typically at high level on all proliferating cell, activated cells and erythroblasts or reticulocytes that require iron, but not on resting peripheral blood leucocytes and mature erythrocytes. CD71 antigen is also expressed at high level on cells of most neoplastic cell lines and 29-32% of bone marrow cells. A soluble form of CD71 in serum (plasma) exists besides a membrane form. Monitoring the soluble form of CD71 antigen in plasma is a diagnostic marker of anemia besides assaying plasma ferritin. The CD71 (HI160) antibody inhibits CD71/Transferrin receptor activity.
Alternate Names: Transferrin receptor protein 1, TfR1, TR, TfR, Trfr, T9, p90, CD71 antigen, TFRC
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P02786, NP_003225
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Yang CY., et al. 1990. ACTA Academiae Medicinae Sinicae. 12(6): 400
Yang CY., et al. 1992. Chinese J. Microbiology and Immunology. 12(3): 178
Yang CY., et al. 1993. Tissue Antigens. 42(4): 253
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
Pathway and Disease: Immune System, Membrane Transport, Signaling Molecules and Interaction
Description:
The CD71 (HI166) Antibody recognizes a 95-kDa disulfide-bonded homodimeric type-II transmembrane glycoprotein called transferring receptor (TfR). CD71 antigen is expressed typically at high level on all proliferating cell, activated cells and erythroblasts or reticulocytes that require iron, but not on resting peripheral blood leucocytes and mature erythrocytes. CD71 antigen is also expressed at high level on cells of most neoplastic cell lines and 29-32% of bone marrow cells. A soluble form of CD71 in serum (plasma) exists besides a membrane form. Monitoring the soluble form of CD71 antigen in plasma is a diagnostic marker of anemia besides assaying plasma ferritin. The CD71 (HI160) antibody inhibits CD71/Transferrin receptor activity.
Alternate Names: Transferrin receptor protein 1, TfR1, TR, TfR, Trfr, T9, p90, CD71 antigen, TFRC
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P02786, NP_003225
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Yang CY., et al. 1990. ACTA Academiae Medicinae Sinicae. 12(6): 400
Yang CY., et al. 1992. Chinese J. Microbiology and Immunology. 12(3): 178
Yang CY., et al. 1993. Tissue Antigens. 42(4): 253
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
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