CD71 (Transferrin Receptor) (clone EBS-CD-040), anti-human

Source:
A BALB/c mouse was immunized with human thymocytes.
Fusion partner: SP2/0.



Specifications:
The transferrin receptor is a type II membrane glycoprotein existing as a homodimer of 180-190 kDa with interchain disculphide bonding. The ligand is the serum iron transport protein transferrin. CD71 is expressed weakly on all resting leucocytes but is upregulated on all cells upon activation, reflecting the iron dependence of proliferation. In other tissues CD71 is expressed on most dividing cells, but also strongly on brain endothelium and alveolar macrophage. CD71 expression can reflect clinical behaviour or response to therapy in a number of malignancies including leukemia, lymphoma and breast cancer.

Species reactivity:
Positive: human.

Applications:
CD71 is an indicator for proliferation.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Western blot: +

Positive control: CCRF-CEM, Jurkat, K-562, human placenta, breast carcinoma.

References:
- Van de Rijn et al. Cytogenet.Cell Genet. 36: 525 (1983).
- Oudermans et al. Cancer. 58: 1252 (1986).
- Beguin Y, et al, Leukemia(12): 2019-25 (1993).
- Rittenhouse-Diakun K, et al.Photochem Photobiol.61(5): 523-8 (1995).
- Lio D, et al, Mech Ageing Dev.89(1): 51-8 (1996).