CD79a polyclonal, anti-human

Protein Family: Cellular Antigens, Receptors and Channels

Pathway and Disease: Immune System

Description:
The CD79a antigen (Immunoglobulin binding protein-1, IGBP-1) is an alpha/beta heterodimer cell membrane protein required in cooperation with CD79b for the initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR). This cascade leads to BCR complex internalization, trafficking to late endosomes and antigen presentation. CD79a is also required for BCR surface expression and efficient differentiation of pro- and pre-B-cells. CD79a interacts with numerous kinases such as SYK, BLNK, Src-family tyrosine kinases. Defects in CD79a are a cause of non-Bruton type agammaglobulinemia, an immunodeficiency disease of the B-cell maturation pathway.

Alternate Names: CD79A, IGBP-1, Immunoglobulin binding protein-1, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Surface IgM-associated protein, Membrane-bound immunoglobulin-associated protein

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P11912

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD79a.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.