CD8 (clone HIT8a) PE, anti-human
€390.00
In stock
SKU
251053
Catalog Nr.: 251053
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Size: 2 ml
Isotype: mouse IgG1
Applications: FC
Protein Family: Cellular Antigens, Cell Adhesion Molecules
Pathway and Disease: Immune System
Description:
The CD8 (HIT8a) antibody recognizes a 68-kDa type-I transmembrane glycoprotein that consists of two disulfide-linked chains that form alpha homodimers or alpha/beta heterodimers. The most frequent CD8 antigen is CD8 alpha/beta heterodimer, which is expressed on 13-48 % peripheral blood suppressor/cytotoxic T lymphocytes (Ts/Tc) and 70-80% thymocytes. In addition, a proportion of γδT cells and NK cells express CD8α homodimers. CD8β requires the presence of CD8a to be expressed on the cell surface. CD8 antigen is co-receptor for HLA class-I molecules.
Alternate Names: T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a antigen, CD8a, MAL
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P01732, NP_001761
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
Shen DC., et al., 1990. Shanghai J. of Immunol. 10(3):147
Yang CY., et al. 1993. J. of Monoclonal Antibody. 9(4):42.
Pathway and Disease: Immune System
Description:
The CD8 (HIT8a) antibody recognizes a 68-kDa type-I transmembrane glycoprotein that consists of two disulfide-linked chains that form alpha homodimers or alpha/beta heterodimers. The most frequent CD8 antigen is CD8 alpha/beta heterodimer, which is expressed on 13-48 % peripheral blood suppressor/cytotoxic T lymphocytes (Ts/Tc) and 70-80% thymocytes. In addition, a proportion of γδT cells and NK cells express CD8α homodimers. CD8β requires the presence of CD8a to be expressed on the cell surface. CD8 antigen is co-receptor for HLA class-I molecules.
Alternate Names: T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a antigen, CD8a, MAL
Application Notes: FC with whole blood: 100 μl blood + 20 μl antibody; FC with cells: 10E6 cells + 20 μl antibody. FC: 1:200-1:1,000
Accession No.: P01732, NP_001761
Format: Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Schlossman S. et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. P246, Oxford University Press, New York
Shen DC., et al., 1990. Shanghai J. of Immunol. 10(3):147
Yang CY., et al. 1993. J. of Monoclonal Antibody. 9(4):42.
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