CD8a (clone 143-44), anti-human

CD8a (clone 143-44), anti-human

€195.00
In stock
SKU
EMC0018-01
Catalog Number: EMC0018-01
Size: 100 μg
Isotype: mouse IgG1-k
Applications: fcm, IHC/F, IF, IHC/P
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Source:
A BALB/c mouse was immunized with human PBL,
Fusion partner: NS-1.



Specifications:
143-44 recognizes a protein of 32 kDa, identified as CD8a. The CD8 molecule consists of α and β-chains, which are disulphide-linked into heterodimers or homodimers. CD8 is expressed on a T-cell subset (cytotoxic/suppressor T-cells), thymocytes and NK-cells. The majority of CD8+ T-cells express CD8 as heterodimer. Some subpopulation of CD8+ T-cells as well as NK-cells may express homodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α-chain but not β-chain. 124-1D1 was assigned at the IVthInternational Workshop.

Species reactivity:
Positive: human.

Applications:
Characterization of leukemia and lymphoma.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: +

Positive control: HuT78 or hPBL. Tonsil.

References:
- Knapp W. et al. Leucocyte typing IV, p. 1076, Oxford University Press, Oxford (1989).
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