CD8a (clone IBL-3/25), anti-mouse

Source:
A Wistar rat was immunized with mouse lymph node cells.
Fusion partner: SP-2/0.



Specifications:
IBL-3/25 is directed against the α-chain of CD8. The CD8 complex consists of a disulphide-linked α/β heterodimer with a MW of 30 kDa or an α/α homodimer with a MW of 32 kDa. The CD8 molecule binds to HLA class I molecules during interaction of CD8+ T-cells with antigen-presenting cells or with target cells. CD8+ T-cells include most of the cytotoxic T-cells.

Species reactivity:
Positive: mouse.

Applications:
Mouse models of Leukemia and Lymphoma.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: -

Positive control: Mouse PBL or lymph node.

References:
- Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, (1989).
- Parnes JR Semin Immunol6: 221-229 (1994).
- Delon J. et al. Immunity9(4): 467-73 (1998).
- Akimoto H, et al. Immunology95(2): 214-218 (1998).
- Leahy DJ. Transplantation45(4): 677-682 (1998).