CDKN1C (clone 3E3), anti-human
€394.00
In stock
SKU
253089
Catalog Nr.: 253089
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Cell Growth and Death
Description:
p57/KIP2 is a potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and to a lesser extent, the mitotic cyclin B-CDC2. p57/KIP2 is a negative regulator of cell proliferation and plays a role in the maintenance of the non-proliferative state throughout life. Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS). BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth and macroglossia.
Alternate Names: Cdkn1c, p57/Kip2, p57, KIP2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57KIP2
Application Notes: WB: 1:500-1:2000
Accession No.: P49918
Antigen: Purified recombinant fragment of human CDKN1C expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
p57/KIP2 is a potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and to a lesser extent, the mitotic cyclin B-CDC2. p57/KIP2 is a negative regulator of cell proliferation and plays a role in the maintenance of the non-proliferative state throughout life. Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS). BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth and macroglossia.
Alternate Names: Cdkn1c, p57/Kip2, p57, KIP2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57KIP2
Application Notes: WB: 1:500-1:2000
Accession No.: P49918
Antigen: Purified recombinant fragment of human CDKN1C expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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