CDKN2A polyclonal, anti-human, mouse

Protein Family: Protein Kinases

Pathway and Disease: Cancers, Cell Growth and Death

Description:
CDKN2A acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This interaction inhibits CDKs binding to cyclins D and phosphorylation of the retinoblastoma protein. Defects in CDKN2A are the cause of numerous cancers such as melanoma and astrocytoma.

Alternate Names: Cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4, p16-INK4a, p16INK4A, Multiple tumor suppressor 1, MTS1, CDKN2A, CDKN2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P42771, NP_000068

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CDKN2A.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by saturated sodium sulfate precipitation.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.