CDw17 (clone EBS-CD-014), anti-human

Source:
A BALB/c mouse was immunized β-2 microglobulin associated proteins from a detergent lysate of human PBL.
Fusion partner: NS-1.



Specifications:
CDw17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CDw17 is found on monocytes, granulocytes, basophils, platelets, a subset of peripheral B-cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T-lymphocytes. CDw17 binds to bacteria and may function in phagocytosis. It may also be involved in angiogenesis. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.

Species reactivity:
Positive: human.

Applications:
EBS-CD-014 can be used for staining of frozen tissues and in flow cytometry.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: ―

Positive control: Human PBL and tonsil.

References:
- Knapp W. Leukocyte Typing IV, Oxford Univ. Press, (1989).