CHD3 (C-terminus) (clone ), anti-human
€388.00
In stock
SKU
MB0061
Background:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Alternative Name:
Chromodomain-helicase-DNA-binding protein 3, CHD-3, Hzfh, Zinc finger helicase, Mi2-alpha, ATP-dependent helicase CHD3
Application Dilution: WB: 1:1000, IHC: 1:500, FC: 1:50~100
Specificity: This antibody detects endogenous levels of CHD3 (C-terminus) and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the C-terminus of Human CHD3.
MW: Predicted band size: 226KDa, Observed band size: 260KDa
Swis Prot.: Q12873
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Alternative Name:
Chromodomain-helicase-DNA-binding protein 3, CHD-3, Hzfh, Zinc finger helicase, Mi2-alpha, ATP-dependent helicase CHD3
Application Dilution: WB: 1:1000, IHC: 1:500, FC: 1:50~100
Specificity: This antibody detects endogenous levels of CHD3 (C-terminus) and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the C-terminus of Human CHD3.
MW: Predicted band size: 226KDa, Observed band size: 260KDa
Swis Prot.: Q12873
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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