CHK1 (clone 2G1D5), anti-human, mouse
€310.00
In stock
SKU
252622
Catalog Nr.: 252622
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: WB
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Replication and Repair, Cell Growth and Death, Infectious Diseases
Description:
CHK1 (Serine/threonine-protein kinase CHK1) is required for checkpoint-medated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. CHK1 phosphorylates Cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by Chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.
Alternate Names: CHEK1, CHK1, Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1
Application Notes: WB: 1: 500-1: 2,000
Accession No.: O14757
Antigen: Purified recombinant fragment of CHK1 expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Replication and Repair, Cell Growth and Death, Infectious Diseases
Description:
CHK1 (Serine/threonine-protein kinase CHK1) is required for checkpoint-medated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. CHK1 phosphorylates Cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by Chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.
Alternate Names: CHEK1, CHK1, Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1
Application Notes: WB: 1: 500-1: 2,000
Accession No.: O14757
Antigen: Purified recombinant fragment of CHK1 expressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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