CK17 (clone 3B12), anti-human
€394.00
In stock
SKU
252903
Catalog Nr.: 252903
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: WB, IHC
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: WB, IHC
Protein Family: Cell Adhesion Molecules, Cytoskeleton Proteins
Pathway and Disease: Signaling Molecules and Interaction, Cancers
Description:
CK17 (Cytokeratin-17) is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Alternate Names: Keratin, type I cytoskeletal 17, 39.1, Cytokeratin-17, Keratin-17, K17, KRT17
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q04695
Antigen: Purified recombinant fragment of CK17 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Cancers
Description:
CK17 (Cytokeratin-17) is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Alternate Names: Keratin, type I cytoskeletal 17, 39.1, Cytokeratin-17, Keratin-17, K17, KRT17
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q04695
Antigen: Purified recombinant fragment of CK17 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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