Cleaved-CASP1 (D210) Polyclonal Antibody

Background:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
CASP-1, CASP1, CASP1, Caspase 1, Caspase-1 subunit p10, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1 beta converting enzyme, IL1B convertase, Interleukin 1 beta convertase, Interleukin 1B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-1

Swissprot: P29466

Calculated MW: 45 kDa
Observed MW: 25 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-2000, IHC 1:50-300, IF 1:50-300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.