Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody

Background:
caspase 4(CASP4) Homo sapiens This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

Alternative Names:
CASP4, ICH2, Caspase-4, Caspase 4, CASP-4, ICE(rel)-II, Protease ICH-2, Protease TX

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 4. AA range:62-111

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 43+22

GeneID: CASP4

Storage: -20°C/1 year

NOTE: For Research Use Only