CLOCK (clone 8F7), anti-human
€346.00
In stock
SKU
252994
Catalog Nr.: 252994
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, FC
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, FC
Protein Family: Enzymes, Transcription Factors
Pathway and Disease: Transcription
Description:
CLOCK (Circadian locomoter output cycles protein kaput) heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. CLOCK activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. CLOCK has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. CLOCK acetylates primarily histones H3 and H4.
Alternate Names: Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, CLOCK, BHLHE8, KIAA0334
Application Notes: WB: 1:500-1:2000; FC: 1:200-1:400
Accession No.: O15516
Antigen: Purified recombinant fragment of human CLOCK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Transcription
Description:
CLOCK (Circadian locomoter output cycles protein kaput) heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. CLOCK activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. CLOCK has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. CLOCK acetylates primarily histones H3 and H4.
Alternate Names: Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, CLOCK, BHLHE8, KIAA0334
Application Notes: WB: 1:500-1:2000; FC: 1:200-1:400
Accession No.: O15516
Antigen: Purified recombinant fragment of human CLOCK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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