CLOCK polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Transcription Factors

Pathway and Disease: Transcription

Description:
CLOCK (Circadian locomoter output cycles protein kaput) heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. CLOCK activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. CLOCK has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. CLOCK acetylates primarily histones H3 and H4.

Alternate Names: Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, CLOCK, BHLHE8, KIAA0334

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:500

Accession No.: O15516

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CLOCK.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.