CNTFR-alpha polyclonal, anti-human
€347.00
In stock
SKU
251968
Catalog Nr.: 251968
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Receptors and Channels
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction
Description:
Ciliary neurotrophic factor receptor subunit alpha (CNTFR) is hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. CNTFR is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
Alternate Names: Ciliary neurotrophic factor receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha, CNTFR
Application Notes: E: 1:1,000-1:30,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P26992
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the venter region of human CNTFR.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction
Description:
Ciliary neurotrophic factor receptor subunit alpha (CNTFR) is hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. CNTFR is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
Alternate Names: Ciliary neurotrophic factor receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha, CNTFR
Application Notes: E: 1:1,000-1:30,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P26992
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the venter region of human CNTFR.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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