Colchicine

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Synonyms: Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;colchicine; 7-alpha-h-colchicine;7alpha-h-colchicine;acetamide, n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(alpha)hepta;len-7- yl)-; n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-acetamide; (s)-yl); n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-acetamide; (s)-yl); benzo(a)heptalen-9(5h)-one;7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5h)-one;colchicin;colchicina;colchicine;colchineos;colchisol;colcin;colsaloid;condylon; n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamid;e; n-acetyl trimethylcolchicinic acid methylether; nsc 757

Light Sensitive

Appearance: Yellow powder
Boiling Point: 726.03 °C at 760 mmHg (Predicted)
Density: 1.26 g/cm3 (Predicted)
IUPAC_Name: N-R03;[(7S)-R03;1,R03;2,R03;3,R03;10-R03;Tetramethoxy-R03;9-R03;oxo-R03;5,R03;6,R03;7,R03;9-R03;tetrahydrobenzoR03;[a]R03;heptalen-R03;7-R03;yl]R03;acetamide
Melting Point: 150-160 °C
RTECS Number: GH0700000

Molecular Weight: 399.44
Molecular Formula: C22H25NO6
Purity: >95%
Storage: RT
Solubility: H2O: 45 mg/mL at 20°C. Soluble in alcohol and chloroform. Practically insoluble in petroleum ether and benzene
Appearance Form: Powder
Appearance Color: White to yellow
Melting Point: 150 - 160°C
EC No.: 200-598-5
Brand Name: bioPLUS™