Collagen II polyclonal, anti-human, mouse, rat, rabbitovine, dog, chicken

Protein Family: CAM Ligands

Pathway and Disease: Cell Communication, Signaling Molecules and Interaction

Description:
Type II collagen (COL2A1) is specific for cartilaginous tissues. Type II collagen is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Defects in COL2A1 are the cause of a variety of chondrodysplasia including hypochondrogenesis and osteoarthritis.

Alternate Names: Collagen alpha-1(II) chain, Alpha-1 type II collagen, chondrocalcin, COL2A1

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P02458

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human type II collagen.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Qian H et al. 2013 Mollecular and cellular Biology. 33(4):661-677. PMID# 23184664.
[2] Wu C et al. 2012. Elsevier. Process Biochemistry. 47(6):922-928. PMID# 23184664