Collagen Type I (clone 5D8), anti-human
€966.00
In stock
SKU
250274
Catalog Nr.: 250274
Size: 0.2 mg
Isotype: Mouse IgG1/k
Applications: E, WB, IHC
Size: 0.2 mg
Isotype: Mouse IgG1/k
Applications: E, WB, IHC
Protein Family: CAM Ligands, Cellular antigens, Receptors and Channels, Cell Adhesion Molecules
Pathway and Disease: Cancers, Signaling Molecules and Interaction, Cell Communication,
Description:
Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Defects in one or both alleles of the type I collagen gene causes "brittle bone disease" (osteogenesis imperfecta). Patients suffering from such defects have low levels of fully functional type I collagen resulting in fragile bones. This antibody is highly specific for native type I collagen and shows no evidence of cross-reactivity with type II, III, V and VI collagens in inhibition ELISA and immunoblotting, and no evidence of cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). The antibody reacts with human, calf, sheep, pig, dog and goat type I collagens in ELISA and immunoblotting, but does not react with mouse, guinea pig, cat, rabbit, squirrel, horse, kangaroo or chicken type I collagen. The antibody has a Ka of approximately 2.5 x 106 M-1 for human type I collagen.
Alternate Names: Collagen alpha-1(I) chain, alpha-1 type I collagen, COL1A1
Application Notes: Product Cat. No. 250274 can be used to detect collagens by ELISA. In immunoblotting Product Cat. No. 250274 detects human type I collagen only in its native triple helix form. Product Cat. No. 250274 can be used in immunohistochemistry with frozen unfixed sections of human and bovine skin. If tissue fixation is required, acetone or ethanol is recommended. E: 1:16,000; WB: 1:1,000; IHC: 1:200
Accession No.: P02452
Antigen: Pepsin-solubilized, salt-fractionated type I collagen from human placenta
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Choi JS et al. 2014. Biomaterials. 40:98-106. PMID#25433606.
Pathway and Disease: Cancers, Signaling Molecules and Interaction, Cell Communication,
Description:
Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Defects in one or both alleles of the type I collagen gene causes "brittle bone disease" (osteogenesis imperfecta). Patients suffering from such defects have low levels of fully functional type I collagen resulting in fragile bones. This antibody is highly specific for native type I collagen and shows no evidence of cross-reactivity with type II, III, V and VI collagens in inhibition ELISA and immunoblotting, and no evidence of cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). The antibody reacts with human, calf, sheep, pig, dog and goat type I collagens in ELISA and immunoblotting, but does not react with mouse, guinea pig, cat, rabbit, squirrel, horse, kangaroo or chicken type I collagen. The antibody has a Ka of approximately 2.5 x 106 M-1 for human type I collagen.
Alternate Names: Collagen alpha-1(I) chain, alpha-1 type I collagen, COL1A1
Application Notes: Product Cat. No. 250274 can be used to detect collagens by ELISA. In immunoblotting Product Cat. No. 250274 detects human type I collagen only in its native triple helix form. Product Cat. No. 250274 can be used in immunohistochemistry with frozen unfixed sections of human and bovine skin. If tissue fixation is required, acetone or ethanol is recommended. E: 1:16,000; WB: 1:1,000; IHC: 1:200
Accession No.: P02452
Antigen: Pepsin-solubilized, salt-fractionated type I collagen from human placenta
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Product Citations:
Choi JS et al. 2014. Biomaterials. 40:98-106. PMID#25433606.
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