Collagen type IV (clone Col-30), anti-human

Protein Family: CAM Ligands

Pathway and Disease: Signaling Molecules and Interaction, Cell Communication, Cancers, Infectious Diseases

Description:
Type IV collagen (collagen type IV) is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in collagen type IV are a cause of Alport syndrome autosomal recessive (APSAR). APSAR is characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks).

Alternate Names: Collagen alpha-4(IV) chain, COL4A4, Collagen type IV, COL4A1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P53420

Antigen: Human collagen type IV.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.