Connexin-43 (Ser368) polyclonal, anti-human, mouse, bovine, dog, chicken, goat, zebrafish
€440.00
In stock
SKU
252529
Catalog Nr.: 252529
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Receptors and Channels
Pathway and Disease: Cell Communication, Development and Behavior, Membrane Transport, Neurodegenerative Disorders
Description:
Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Phosphorylation of Ser368 by PKC induces a conformational change of connexin-43 that results in a decrease in gap junction permeability. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities.
Alternate Names: Connexin-43, Gap junction alpha-1 protein, Cx43, Gap junction 43 kDa heart protein, GJA1, GJAL
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P08050
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser368 of rat connexin 43.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cell Communication, Development and Behavior, Membrane Transport, Neurodegenerative Disorders
Description:
Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Phosphorylation of Ser368 by PKC induces a conformational change of connexin-43 that results in a decrease in gap junction permeability. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities.
Alternate Names: Connexin-43, Gap junction alpha-1 protein, Cx43, Gap junction 43 kDa heart protein, GJA1, GJAL
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P08050
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser368 of rat connexin 43.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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