Cortactin (Acetyl Lys235) Polyclonal Antibody

Background:
cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010],

Alternative Names:
CTTN, EMS1, Src substrate cortactin, Amplaxin, Oncogene EMS1

Immunogen: Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235.

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 62

GeneID: CTTN

Storage: -20°C/1 year

NOTE: For Research Use Only