CREB-1 polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
250613
Catalog Nr.: 250613
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Transcription Factors
Pathway and Disease: Endocrine System, Cancers, Immune System, Transcription, Signal Transduction
Description:
As a dimer, CREB-1 (cAMP-responsive element-binding protein 1) binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters, to stimulate transcription. CREB-1 is activated by phosphorylayion on Ser-133 and Ser-142. Transcriptional activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. CREB-1 has been implicated in synchronization of circadian rhythmicity. It interacts with various proteins including TORC/CRTC, CREBBP, ARRB1.
Alternate Names: Cyclic AMP-responsive element-binding protein 1, cAMP response element-binding protein, CREB, CREB1, CREB-1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P16220
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CREB-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Endocrine System, Cancers, Immune System, Transcription, Signal Transduction
Description:
As a dimer, CREB-1 (cAMP-responsive element-binding protein 1) binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters, to stimulate transcription. CREB-1 is activated by phosphorylayion on Ser-133 and Ser-142. Transcriptional activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. CREB-1 has been implicated in synchronization of circadian rhythmicity. It interacts with various proteins including TORC/CRTC, CREBBP, ARRB1.
Alternate Names: Cyclic AMP-responsive element-binding protein 1, cAMP response element-binding protein, CREB, CREB1, CREB-1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P16220
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CREB-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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