Crk2 (clone ), anti-human
€388.00
In stock
SKU
MB0130
Background:
Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.
Alternative Name:
Adapter molecule crk, Proto-oncogene c-Crk, p38 CRK, CRK, CRKII
Application Dilution: WB: 1:1000
Specificity: Crk2 mAb detects endogenous levels of Crk2 protein.
Immunogen:
Recombinant full length Human Crk2.
MW: Predicted band size: 34kDa , Observed band size: 34kDa
Swis Prot.: P46108
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.
Alternative Name:
Adapter molecule crk, Proto-oncogene c-Crk, p38 CRK, CRK, CRKII
Application Dilution: WB: 1:1000
Specificity: Crk2 mAb detects endogenous levels of Crk2 protein.
Immunogen:
Recombinant full length Human Crk2.
MW: Predicted band size: 34kDa , Observed band size: 34kDa
Swis Prot.: P46108
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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