CSK (clone 5F3), anti-human, mouse, rat, Mk
€394.00
In stock
SKU
253076
Catalog Nr.: 253076
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IF
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IF
Protein Family: Enzymes, Protein Kinases, Receptors and Channels
Pathway and Disease: Cancers, Development and Behavior, Signal Transduction, Transcription
Description:
Csk (Carboxy-terminal Src kinase) is a ubiquitously expressed nonreceptor tyrosine kinase. Csk negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK. This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk. It is expressed in lungs and macrophages.
Alternate Names: Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000;
Accession No.: P41240
Antigen: Purified recombinant fragment of human CSK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Development and Behavior, Signal Transduction, Transcription
Description:
Csk (Carboxy-terminal Src kinase) is a ubiquitously expressed nonreceptor tyrosine kinase. Csk negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK. This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk. It is expressed in lungs and macrophages.
Alternate Names: Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000;
Accession No.: P41240
Antigen: Purified recombinant fragment of human CSK expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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